Our nutrients must be a remedy,
and our remedies must be nutrients.
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Dear reader, I bring to your attention a short translation of the article by James M. Greenblatt and co-authors posted on the websitePsychiatrictimes.
The genesis of depression is not fully understood. There are many theories for the development of this disease and many different treatment options that are not always effective. Therefore, in my opinion, in the treatment of depression, it is worth considering the multifactorial nature, including the effect of food. I don’t know whether it is worth consuming micronutrient supplements, but the fact that you can eat foods containing pro-substances of mood hormones that regulate moods is true.
Minerals play a crucial role in supporting several key functions related to mood disorders, including transmission of nerve impulses, cellular metabolism, and immunocompetence. Micronutrient deficiencies in food are common in both low-income and industrialized countries due to excessive consumption of refined sugars and unbalanced foods.
The importance of various nutrients for mental health has been established, but the question of whether malnutrition is the cause or consequence of poor mental health continues to be debated. However, the prevalence of malnutrition among people with depression is undeniable.
In a study of the population, which included 13,486 children and adolescents, malnutrition correlated with increased aggressiveness, violent behavior, and mental illness. Earlier clinical studies also showed a positive correlation between rates of depression and poor nutrition. In a study of 184 elderly participants, nutritional deficiencies and concomitant depression were identified in 50% of cases.
The role of trace elements in the pathophysiology of depression
Current research illustrates the wide range of mental health complications that can arise from a lack of micronutrients, including impaired cognitive function (attention, memory, thinking) and effects on brain morphology. Trace elements are vital in the enzymatic reactions responsible for the synthesis and preservation of neurotransmitters, and mineral deficiency has been identified in the pathophysiology of depressive symptoms.
Minerals are essential for the enzymatic activation of brain neurotrophic factor (BDNF), a protein that regulates the plasticity of neurons and promotes the maturation and differentiation of new neurons in the central nervous system and peripheral nervous system. Animal studies have shown that stress can reduce BDNF activity in the hippocampus, and clinical studies show similar results in which serum BDNF levels are lower in depressed patients than in controls.
Small-scale studies have proven that zinc therapy enhances the effectiveness of antidepressants (SSRIs and tricyclic antidepressants)
Magnesium as a modulator of stress response systems.
Magnesium is a divalent cation that plays a fundamental role in the intermediate metabolic processes in living systems. It functions as a central regulator of metabolism and a modulator of calcium and potassium transport. Like other trace elements, magnesium enters the body through food. It is second only to potassium in the concentration in mammalian tissues and is involved in more than 300 vital biochemical reactions in the human body.
Like zinc, magnesium is crucial for enzymatic, hormonal and neurotransmitter processes. The first report on the role of magnesium in the genesis of depression appeared almost a century ago. In 1921, magnesium became the first medicine-recognized substance to be used to treat depression. Magnesium has been used successfully to treat 220 of the 250 study participants who were initially presented with agitated depression. After this study, empirical evidence continued to confirm the effectiveness of magnesium.
Studies show that taking magnesium can relieve depressive symptoms, while magnesium deficiency can reduce stress resistance.
Under stress, the human brain activates a consistent neurobiological reaction that prepares a person to deal with an immediate threat. Long-term exposure to psychological pressure can trigger a chronic effect of adaptive stress mechanisms, as evidenced by elevated serum cortisol levels.
Under normal conditions, the corresponding stress response is activated when the hypothalamus releases corticotropin-releasing hormone (CVH) to signal adrenocorticotropic hormone (ACTH) to release cortisol from the adrenal glands. Activating this pathway starts a feedback loop to suppress CVH production until the body recovers homeostasis. However, in conditions where chronic stress predominates, for example, with depression and anxiety, hyperactivation of the hypothalamic-pituitary-adrenal axis (GGN) and constant elevated levels of cortisol leads to the fact that neurons demyelinate, degrade and eventually die.
Magnesium helps in altering the stress response through the GGN axis, decreasing the secretion of ACTH, modulating adrenocorticotropic sensitivity to ACTH, and preventing stress hormones from entering the brain. However, in the presence of chronic stress exposure in combination with magnesium deficiency, the GGN axis cannot respond effectively.
Although scientific research is scarce, available evidence confirms the presence of magnesium as a promising adjuvant therapy.
A cross-sectional study of 402 Iranian students also demonstrated the relationship between inadequate intake of magnesium with food and depressive symptoms.
Earlier clinical studies have also illustrated the ability of magnesium to reduce depression and chronic fatigue, showing a synergistic effect in tandem with some antidepressants.
A number of other diseases are also associated with magnesium deficiency (diabetes, metabolic syndrome, hypertension). Thus, the decline in dietary magnesium over the past century should be worrisome: approximately 45% of the US population consumes less than the recommended daily allowance.
Assessment of the role of nutraceuticals in clinical practice
Depression is a chronic disease: most patients have unresolved symptoms despite treatment with antidepressants. The pathophysiology of depressive disorders is associated with various dysfunctional biochemical mechanisms, such as monoamine disturbance, BDNF activity, and neuroendocrinological changes. Minerals are vital for achieving optimal cognitive function. They function as part of larger cellular processes, mobilizing the synthesis of neurotransmitters, activating hundreds of key enzymes, modulating the activity of receptors and regulating immunological reactions.
Inadequate levels of zinc and magnesium have a direct, visible effect on biomarkers of mood and behavior. The targeted mineral supplement has the potential to improve outcomes in clinical symptoms. Changes in other minerals, including chromium, copper, iron, and lithium, are also key participants in neurochemical reactions that affect mood and behavior. The determination of the level of trace elements should be an integral part of the assessment, treatment and prevention of mood disorders.
The additional use of nutraceuticals can improve the therapeutic efficacy of pharmacological treatment by modulating the underlying neurobiological mechanisms. The effectiveness of this type of treatment will be evaluated in the planned large-scale studies.
Illustration: Floris van Schouten. Kitchen still life.
A breakthrough in medicine, known only to scientists!
A breakthrough nutrition study conducted at Larner College of Medicine at the University of Vermont found that only 248 mg of magnesium per day will eliminate the symptoms of depression! This is absolutely official data published in a scientific journal. Plos on and recognized by the scholarly community, assured Mike Adams in his article on Natural News.
But why is this not heard at every corner?
“New clinical research results show that magnesium is effective in relieving symptoms and is safer and cheaper than prescription treatments,” Science Daily reports.
This is further evidence that even orthodox science now recognizes that magnesium is a safe, affordable, and effective treatment for depression.
But with all this, on television and in the press, they continue to bomb us with advertisements for dangerous pharmaceuticals that are addictive and fish out our money.
Only a quarter gram of magnesium is all that is needed, and it costs a mere penny!
In addition, the powerful nutritional properties of magnesium help prevent mineral deficiency and chronic diseases of various organs, and improve the cardiovascular system, brain, kidneys and much more.
However, for some reason, doctors and pharmacists are not talking about health care reform, and the use of natural remedies. This could save billions of government funds on purchases of ineffective bullion.
It's all about mutual responsibility, says Mike Adams.
After all "Great pharmacology" (Big Pharma) is a huge multibillion-dollar business, and it is more profitable for government officials to get finances from the budget for the purchase of promoted chemicals than to switch to cheap natural resources and cut off cash flows through their hands.
Adams talks about the American health care system, but we have the same thing, right?
Omega 3 Fatty Acids
Numerous studies show that EPA, DHA and ALA (the three main chemicals containing Omega-3 PUFAs) have powerful mood-enhancing properties. CNS Neuroscience & Therapeutics published a review of three studies proving that omega-3 fatty acid supplements were more effective than placebo in treating depression in children and adults. Not surprisingly, these polyunsaturated fats (PUFAs) give positive results in treating depression, given that our brain tissues (including brain cell membranes) are actually made up of omega-3 fatty acids.
Since our body cannot synthesize Omega-3 fatty acids, we need to get them from food and nutritional supplements. Undoubtedly, the best source of omega-3 fatty acids in the world, and thus one of the best natural remedies for depression, is fish oil. The purified form of triglycerides of fish oil is generally cleaner and better absorbed than the standard forms of omega-3 ethyl esters.
S-adenosylmethionine or SAMe is a chemical compound present in every cell in our body. Thanks to a complex series of metabolic reactions, it is converted into mood-regulating neurotransmitters, such as serotonin, dopamine, and norepinephrine, which support cognitive function. Therefore, depression is often the first sign of SAMe deficiency. Studies have shown that people diagnosed with clinical depression often have unusually low levels of SAMe in their brain.
Therapeutic doses of SAMe range from 400 to 1300 mg per day. For optimal results, take SAMe in combination with a complex of B vitamins, as some B vitamins (especially B6, B9 and B12) help prevent the conversion of SAMe to homocysteine, an amino acid involved in the development of atherosclerosis, hypertension and other cardiovascular diseases.